Dr. Olivier M. Dorchies is a biochemist and physiologist by education and a pharmacologist by training. For 25 years, he has been working on muscle physiology and pathology, using in vitro and in vivo techniques.

Using murine models of Duchenne muscular dystrophy and X-linked myotubular myopathy, he developed four major lines of research: understanding pathogenic mechanisms, evaluating compounds of therapeutic value (essentially nutraceuticals and repurposed drugs), developing models that are better phenocopies of the human diseases, and establishing standard operating procedures for better preclinical research.

In the last 15 years, his work with green tea polyphenols, rimeporide and tamoxifen in mouse models of Duchenne muscular dystrophy promoted the clinical trials SUNIMUD, RIM4DMD and TAMDMD. His recent work on the protective effects of tamoxifen and the roles of estrogenic signalling in X-linked myotubular myopathy inspired the clinical trial TAM4MTM-UK. His current work towards improving muscle function for DMD patients includes the evaluation of tamoxifen combined to L-citrulline and metformin, a panel of anti-fibrotic compounds, and branched-chain aminoacids.