Duchenne UK funds study to improve our knowledge of heart care in patients with DMD 12 May 2021 Duchenne UK have funded a study that aims to improve our knowledge of treating heart muscle disease in patients with Duchenne muscular dystrophy (DMD). Almost all people with DMD will develop heart muscle disease, or cardiomyopathy, at some stage. There are drugs that are believed to slow down damage and protect the heart. However, no clear data exists for their effective use in DMD. In 2011, a clinical trial, called The Heart Protection Study, was set up to see if starting two existing heart medications in combination (perindopril and bisoprolol) could protect against the development of heart muscle weakness in young boys with DMD. The trial included 75 patients – 5-13 years old at entry, and ended in 2018 when all patients had completed three years of follow-up. The results did not show that there was any difference between boys on active as compared to dummy treatments in terms of reduction in the damage to heart. However, this negative outcome could have occurred for a number of reasons. Most participants were also taking steroids, which is known to delay the onset of cardiomyopathy by about two years. Also, DMD progresses at different rates, so these young patients may not yet have been affected by cardiomyopathy. That’s why Duchenne UK is giving a grant of £68,496 to Dr John Bourke at the Newcastle Upon Tyne NHS Foundation Trust to further study the information from that trial to see if we can get clearer answers about the value of these medications. Our grant will enable Dr Bourke to follow up on the same patients who were in the original trial, and use data collected from them in the years since the trial ended in 2018. The patients continued the heart medications meaning that there are now an additional 3 years of heart reviews, collected as part of their regular check-ups. This should give us a clearer picture of the impact of these two drugs on heart function. The advantages of this study are that there is little inconvenience to patients and their families, with no extra hospital visits; a short study time frame of only 10 months; and all preparatory work in place. Also, if the hoped-for benefits of these two drugs is confirmed, then these medicines are readily available and could be routinely prescribed even earlier in boys with DMD. Duchenne UK is very supportive of examining patient data to help us understand more about DMD and to identify potential treatments. We would like to thank Dr John Bourke for bringing this study to our attention and we look forward to sharing the results with you. We would like to thank our charity partner, Alex's Wish, and the following Family Funds for contributing to this project: Jack’s Mission, Help Harry, Archie’s March, Team Dex, Jacobi’s Wish, William’s Fund, Team Oscar, Following Felix, Ralphy’s Fund, Defending William Against DMD, Love for Leon, Henry’s Hurdles, Ben vs Duchenne, Moving Muscles for Marcus. Q & A What is cardiomyopathy? The heart is a muscle and consequently is affected in DMD. Heart muscle disease is called ‘cardiomyopathy’. It makes it harder for the heart to pump blood around the body. As DMD advances it can cause symptoms such as breathlessness, fatigue, rapid heartbeats and dizziness, and can eventually lead to heart failure. People with DMD tend to develop problems with their heart between the ages of 10 and 15 years. How could this study benefit people with DMD? This study could provide convincing evidence that the two heart drugs combined, perindopril and bisoprolol , successfully delay the onset of cardiomyopathy. Perindopril is an ACE inhibitor and Bisoprolol is a beta blocker, both types of medication that help control blood pressure and improve blood flow to the heart. If a clear benefit is shown, these drugs could be recommended for treatment in DMD, potentially extending patients’ lives. Are there recommendations around starting cardiac care? In the Treat-NMD Guide to Families (2018), there is a section on cardiac management (page 24). Cardiologists, or heart specialists, should see young people with DMD once a year, from diagnosis, and should be a part of their care team. Regular electrocardiogram (ECGs) and echocardiogram (echo) or cardiac MRI should take place. The current international care guidelines say that DMD patients should start an ACE inhibitor by age 10. However, the DMD Care UK project is currently looking into the recommendations for cardiac management, as part of their review of the standards of care. To find out more about the project, please visit dmdcareuk.org. When will we know the outcome of this study? This study will start in April 2021 and be completed within 10 months, with initial results expected before the end of 2022. NOTES FOR EDITORS About Duchenne UK Duchenne Muscular Dystrophy (DMD) is a devastating muscle-wasting disease. It is the most common and severe form of Muscular Dystrophy. Diagnosed in childhood, it mainly affects boys. There is currently no cure. Started by families affected by the disease, Duchenne UK has one clear aim – to end Duchenne. Duchenne UK are funding research that’s focused on getting treatments to those affected now – as well as pushing for an effective treatment in the future. Duchenne UK connects leading researchers with industry, the NHS and patients to challenge every stage of drug development, from research to clinical trials to drug approval. They connect families with each other to create a network of mutual support and to pool resources, knowledge and experience. How to donate COVID-19 has caused a funding crisis in medical research. But we cannot, and will not, let it slow us down in our mission to find new and effective treatments for DMD. Because this generation of boys cannot wait. Donate now, and together we will end Duchenne Duchenne UK is entirely reliant on donations. This can be done via: Direct Debit – Duchenne Direct Individual Donation – Donate If you are a family or friend affected by DMD you can set up your own fund with Duchenne UK – Family and Friend Funds Take part in one of our fundraising events – Events Text DUCHENNE to 70085 to donate £5. This costs £5 plus a std rate msg.