NutrInD: Nutrition In Duchenne Study
Assessing Energy Expenditure, Dietary Intake and Body Composition in People with Duchenne Muscular Dystrophy.
Participation in the study involves 1 visit to the Metabolic Research Unit in the New Lister Building, Glasgow Royal Infirmary for:
1. Weight, height, and length of forearm measurements.
2. Body fat and muscle stores measurements.
3. Consumption of a special type of water (like tap water - totally safe) and provision of 3 saliva samples.
4. Measurements of the number of calories the body burns at rest and during different activities.
5. Completion of questionnaires about health & medication, usual food intake, and physical activity.
Following the visit, participants will need to:
1. Wear a heart rate monitor on the wrist (like a watch) for 7 days.
2. Record food and drink consumption for 4 days.
We are looking for participants from across the UK. Study-related travel expenses and overnight accommodation (if traveling from outside Glasgow) will be reimbursed. Compensation for participants' time will be offered upon study completion.
To find out more about this study and to register your interest in taking part, please contact the study team:
Phone: 07484 536272 (call or text)
Email: med-sch-nutrind@glasgow.ac.uk
Primary Outcome Measures
• Total Energy Expenditure (How much energy the body needs in a day).
• Physical Activity Level (How many calories the body burns with physical activity) & Habitual Physical Activity Patterns.
• Habitual Energy Intake & Diet (How much, how often, and what type of food is consumed).
• Body Composition (What is the percentage of fat and muscle in the body).
Can I take part?
Inclusion Criteria
Ambulant males with DMD
- Ambulant males (defined as able to walk around the house independently without assistance) with DMD
- Aged 5 to 16 years (inclusive of 16 years)
- On daily corticosteroid therapy (Prednisolone, Deflazacort, or Vamorolone) for at least 12 months
Non-ambulant males with DMD
- Non-ambulant males (defined as unable to walk around the house independently without assistance) with DMD
- Aged 10 to 21 years (inclusive of 21 years)
- On daily corticosteroid therapy (Prednisolone, Deflazacort, or Vamorolone) for at least 12 months
Exclusion Criteria
Ambulant males with DMD
- A secondary major chronic or genetic medical diagnosis (other than DMD)
- Unable to provide informed consent
Non-ambulant males with DMD
- A secondary major chronic or genetic medical diagnosis (other than DMD)
- Need for the use of day-time assisted ventilation
- Presence of severe nutritional problems (e.g., gastrostomy feeding)
- Unable to provide informed consent
Age
5 - 21 years
Mutation Specific
Muscle Biopsy
Not Required
Ambulation
both